New Therapeutic Approach for Treatment of Age-Related Macular Degeneration
The scientists discovered that the inhibition of Runt-bound transcription factor 1 (RUNX1), which has been linked to retinal neovascularization and the development of abnormal blood vessels leading to vision loss, presents a new therapy approach to treat age-related macular degeneration (AMD). Their results are published in the American Journal of Pathology . Abnormal growth of blood vessels, or aberrant angiogenesis, originates from the choroid, a portion of the eye behind the retina. This condition, known as choroidal neovascularization (CNV), is present in many eye diseases that lead to blindness like AMD. This study is the first to include RUNX1 in CNV and to test RUNX1 inhibition therapy for the treatment of CNV. The researchers found that the application of a RUNX1 inhibitor alone or in combination with standard therapy for AMD may represent a significant therapeutic advance. The incomplete response to anti-vascular drugs with endothelial growth factor (VEGF) is a critical probl...